Sub chronic toxicity effect of combination of herbal juice on the function and 2 histopathology feature of male Wistar rat liver

Abstract Background: Previously, the activity test of combination herbal juice garlic, rosella flower, red ginger, lime, apple cider vinegar, and honey, combined can lower blood sugar [1] reduce total cholesterol levels [11]. In use traditional medicine its effectiveness, safety must also be proven before juices are circulated in community Objective: This study was to determine subacute hepatotoxic effect Method: research is an experimental using 24 rats divided into four groups. Namely, control group given distilled water, at a dose 28, 14, 7 mg/kg BW/day for 28 days. The measurement parameters were increased SGOT SGPT histopathological features liver cells. data statistically analyzed with one-way ANOVA analysis Results: administration days did not increase but caused significant decrease levels, namely by 20.34%, 19.39%, 15.30%. From picture cells, BW/day, there no damage cells Conclusion: Subacute cause hepatotoxicity Wistar male white Keywords: Combination juice, toxicity, histopathology, SGOT,